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J Korean Soc Emerg Med > Volume 18(5); 2007 > Article
Journal of The Korean Society of Emergency Medicine 2007;18(5): 406-413.
Relationships between beta-fibrinogen gene -455 G/A Polymorphism, 448 G/A Polymorphism, and Plasma Fibrinogen Concentration in Korean Ischemic Stroke Patients
Jong Seok Lee, Han Jin Cho, Han Sung Choi, Hoon Pyo Hong, Young Gwan Ko
Department of Emergency Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. hsg3748@freechal.com
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the beta-fibrinogen gene -455 G/A and 448 G/A polymorphisms and to determine the relationship of these single nucleotide polymorphisms with plasma fibrinogen concentration and with the development of ischemic stroke in Korea.
METHODS:
123 patients who were diagnosed with ischemic stroke at Kyung Hee University Hospital from March 2003 to February 2004 were compared to 230 control subjects. The genotypes of the beta-fibrinogen gene -455 G/A and 448 G/A polymorphisms were confirmed by polymerase chain reaction (PCR), and the allele frequencies of the patient group were compared to those of the control group. The associations of the single nucleotide polymorphisms with development of ischemic stroke and risk factors of ischemic stroke were assessed.
RESULTS:
The patient group had more heterozygotes (G/A or A/G) in the beta-fibrinogen gene than did the control group, and statistical analysis of the genotype frequencies indicated a significant difference between the patient group and the control group (p<0.05). The odds ratios of the allele frequencies were 1.53(95% CI; 1.03-2.29) for the -455 G/A polymorphism and 1.85(95% CI; 1.25-2.74) for the 448 G/A polymorphism, indicating a statistically significant difference between the patient and control groups. In ischemic stroke patients, the allele frequencies for smoking history and hyperfibrinogenemia yielded odds ratios of 1.96(95% CI; 1.17-3.27) and 2.40(95% CI; 1.31-4.40), respectively, for the -455 G/A polymorphism and 1.96(95% CI; 1.19-3.22) and 2.42(95% CI; 1.34-4.39) for the 448 G/A polymorphism.
CONCLUSION:
The -455 G/A and 448 G/A single nucleotide polymorphisms of the beta-fibrinogen gene appear to be associated with plasma fibrinogen concentration and the development of ischemic stroke in Korea.
Key words: Stroke, Fibrinogen, Genetics, Single nucleotide polymorphism
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