| Home | E-Submission | Sitemap | Contact Us |  
J Korean Soc Emerg Med > Volume 17(5); 2006 > Article
Journal of The Korean Society of Emergency Medicine 2006;17(5): 419-423.
Predictive Value of C-reactive Protein for Diagnosis of Acute Perforated and Non-perforated Appendicitis
Yun Joo Moon, Se Min Choi, Un Jung Lee, Kyu Nam Park, Mi Jin Lee, Won Jae Lee
Department of Emergency Medicine, College of Medicine, The Catholic University of Korea. limleeem@catholic.ac.kr
This study was to determine the relationships between C-reactive protein (CRP) level of acute perforated and nonperforated appendicitis.
We retrospectively investigated 200 patients who was diagnosed to appendicitis in emergency medical center from January 2005 to August 2005. All patients were operated for suspected acute appendicitis and diagnosis was confirmed by histology after operation. The patients were divided two groups: group A with nonperforated appendicitis and group B with perforated appendicitis. We assessed and compared epidemiologic, clinical and laboratory data between two groups. For comparison of diagnostic value, the receiver operating characteristic (ROC) curve and the logistic regression analysis were done.
Of the 200 patients, 149 patients were group A, and 51 patients were group B. The mean CRP level in the group B was higher than in patients with group A (109.25+/-87.18 mg/L vs 20.39+/-39.34 mg/L, p<0.05). Also WBC counts was higher in the group B (15.43+/-5.58x1000/microliter vs 12.47+/-4.5x1000/microliter, p<0.05). Though the area under the ROC curve (AUC) of CRP level was greater than WBC counts (0.853 vs 0.659), so CRP level was found to be significantly superior to WBC count in predicting perforated appendicitis. In logistic regression analysis, CRP level (odds ratio 1.024, 95% CI 1.016 to 1.035) was only independent predictor of perforated appendicitis.
Increased CRP level in patients who were suspected appendicitis in emergency medical center was valuable in predicting perforated appendicitis. In such circumstances, we should consider the necessities of preoperative antibiotics, the surgical techniques and the early aggressive management for postoperative complications.
Key words: C-reactive protein, Appendicitis, Postoperative complications
Editorial Office
The Korean Society of Emergency Medicine
TEL: +82-62-226-1780   FAX: +82-62-224-3501   E-mail: 0012194@csuh.co.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Emergency Medicine.                 Developed in M2PI