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Journal of The Korean Society of Emergency Medicine 2008;19(1): 82-87. |
| S-100B Protein as a Useful Serologic Marker of Acute Stroke with Nonspecific Neurologic Symptoms |
| Maeng Real Park, Ji Yun Ahn, Bum Jin Oh, Won Kim, Kyung Soo Lim |
| Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Korea. bjoh@amc.seoul.kr |
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| ABSTRACT |
PURPOSE:
There is a distinct probability of severe complications with stroke unless patients are administered proper treatment at the optimal time. S-100B protein has been reported to be elevated in brain injuries. The current study investigates the efficacy of serum S-100B protein administration during the diagnostic process for patients who have had an acute stroke.
METHODS:
We prospectively recruited the patients with nonspecific neurological symptoms. Non-specific neurological symptoms were defined as no focal neurological deficits or stroke suspected symptoms with NIHSS score zero. We grouped the patients according to the presence of a brain lesion (positive vs negative group) by computed tomography or magnetic resonance imaging. Using serum S-100B protein together with CT/MRI imaging at the time of diagnosis, the cutoff value, sensitivities, and specificities were calculated in making a diagnosis of acute stroke.
RESULTS:
Thirty one patients were enrolled. The level of serum S-100B protein was higher in positive group (median 0.201, interquartile range 0.134-0.469) than in negative group (0.085, 0.060-0.106, p=0.001). In diagnosing acute stroke, the sensitivity was 90.9% at a cutoff value for serum S-100B protein of 0.10 microgram/L . At the cutoff level of serum S-100B protein and the specificity was 75.0%.
CONCLUSION:
The current results suggest that serum S-100B protein may be a useful serologic marker for detecting acute stroke that is suspected with non-specific neurological abnormalities. Further studies are necessary to use the marker as a screening method for acute strokes. |
| Key words:
S-100B protein, Stroke, Neurologic deficits, Serologic Tests, Diagnosis |
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