| Early Detection and Prognosis Prediction of Severe sepsis and Septic shock in Emergency Triage Room |
| Sung Hoon Beak, Kyoung Mi Lee, Dae Young Hong, Seung Baik Han, Kang Ho Kim, Jun Sig Kim, Ji Yoon Kim, Ji Hye Kim, Hwan Cheol Kim |
1Department of Emergency Medicine, Gachon University, Gil Medical center, Incheon, Korea. yongem@gilhospital.com
2Department of Emergency Medicine, Sungkyunkwan University School of Medicine, Masan Samsung Hospital, Masan, Korea. |
|
|
|
|
|
| ABSTRACT |
PURPOSE:
Biochemical markers can help predict neurological outcome in post-resuscitation patients. This prospective study evaluated the prognostic value of serum S100B protein and neuron-specific enolase (NSE) time courses in predicting unfavorable neurological outcomes.
METHODS:
We serially measured serum S100B protein and NSE levels 12 times during the 96 h after the return of spontaneous circulation (ROSC) in 40 patients. Neurological outcome was assessed at 6 months after cardiac arrest.
Patients were divided into good (CPC 1 to 2) and poor (CPC 3 to 5) neurological outcome groups and assessed for cerebral performance category scores. We compared the two groups at each serum value and calculated cut-off values.
RESULTS:
Serum S100B protein levels over the study period, except at 4 hours, and NSE levels from 14 hours after ROSC were significantly higher in the poor neurological outcome group (n=32) than the good neurological outcome group (n=8).
The most predictive serum S100B protein and NSE times were at 14 hours (cut off value=0.16 microgram/L, sensitivity 81.8%, specificity 100%, AUC=0.938) and 54 hours (cut off value=19.21 microgram/L, sensitivity 86.4%, specificity 100%, AUC=0.932).
CONCLUSION:
Serum S100B protein and NSE levels are early and useful markers for assessing neurological outcome after successful resuscitation from cardiac arrest. |
| Key words:
S100B protein, Phosphopyruvate Hydratase, Heart arrest, Prognosis |
|
PDF Links
Full text via DOI 
Download Citation 
