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J Korean Soc Emerg Med > Volume 19(6); 2008 > Article
Journal of The Korean Society of Emergency Medicine 2008;19(6): 665-671.
Practical Application of Semiquantitative Procalcitonin Test in Emergency Department
Sung Wook Kim, Young Min Oh, Se Min Choe, Gyeong Ho Choe, Kyu Nam Park, Joo Suk Oh
Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. holiday1@hanafos.com
Procalcitonin (PCT) is a good marker of infection but is still not routinely used. Here, we assessed the usefulness of a semi-quantitative procalcitonin test kit (PCT-Q(R)), a rapid and simple test for evaluating sepsis in the emergency department.
We recruited 80 patients who visited the emergency center and with systemic inflammatory response syndrome (SIRS). Patients were classified into 4 groups according to PCT levels using PCT-Q[Ed-Trademark signs only have to be given one time in a document]. Mortality rate, bacteremia, severity score, and severity of sepsis (SIRS/sepsis/severe sepsis/septic shock) were assessed with the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. We calculated a receiver operating characteristic curve (ROC curve), cut-off value, and the related diagnostic parameters of each cut-off value.
Higher PCT levels were significantly associated with increased mortality, bacteremia, and severity scores. PCT levels could discriminate between sepsis and severe sepsis at a threshold of 2 ng/ml.
PCT-Q is a prognostic marker of infectious disease, but low levels do not always indicate a good prognosis. PCT levels increase with aggravation of sepsis, especially at values greater than 2 ng/ml for severe sepsis.
Key words: Procalcitonin, Emergency medicine, Reagent strips
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