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J Korean Soc Emerg Med > Volume 21(4); 2010 > Article
Journal of The Korean Society of Emergency Medicine 2010;21(4): 520-523.
A Case of Fatal Fenazaquin Intoxication Showing Severe Lactic Acidosis
Byung Kook Lee, Kyung Woon Jeung, Hyun Ho Ryu, Tag Heo, Yong Il Min, Hyoung Youn Lee
1Department of Emergency Medicine, School of Medicine, Chonnam National University, Gwangju, Korea. neoneti@hanmail.net
2Field Medicine Department, School of Military Medicine, Daejeon, Korea.
Fenazaquin (4-[[4 (1,1-dimethylethyl) pheynyl]ethoxy]quinazoline) is an insecticide that inhibits NADH ubiquinone oxidoreductase of the mitochondria, which is also known as complex I. An 83 year old female was brought to our emergency department (ED) having been found collapsed and unconscious at home by her family. She had ingested up to 100 ml from a bottle of 20% fenazaquin solution. In the ED, she showed severe persistent lactic acidosis despite a seemingly stable hemodynamic condition. Despite intensive supportive management, including positive pressure ventilation, packed red cell transfusion, hemodialysis, and intravenous N-acetylcysteine administration, the lactic acidosis did not respond. To our knowledge, this is the first report of fenazaquin poisoning in humans. No antidote for fenazaquin is known. In this case report, we discuss clinical characteristics and possible pathophysiologic mechanism of fenazaquin poisoning with a literature review.
Key words: Quinazolines, Poisoning, Lactic acidosis
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