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J Korean Soc Emerg Med > Volume 22(1); 2011 > Article
Journal of The Korean Society of Emergency Medicine 2011;22(1): 22-29.
Successful Hemostasis by the use of Recombinant Factor VIIa in Uncontrolled Active Hemorrhage of Multiple Trauma Patients
Yong Min Joo, Seok Ran Yeom, Ji Ho Ryu, Jin Woo Jeong, Yong In Kim, Mun Ki Min, Sung Wook Park, Suck Ju Cho
Department of Emergency Medicine, School of Medicine, Pusan National University, Busan, Korea. seokrany@pusan.ac.kr
Uncontrolled bleeding is a leading cause of death in multiple-injury patients. It is very difficult to control hemorrhage due to microvascular injury in soft tissue by surgery or vascular intervention. Thus, hemostatic agents such as recombinant activated coagulation factor VII (rFVIIa) have become popular with regard to reducing transfusion volumes and correcting the hemorrhage-associated coagulopathy.
From March 2007 to January 2010 we used rFVIIa in 15 multiple-injury patients. Transfused packed red blood cell (pRBC) volume was compared before and 6 h after administration of rFVIIa. Complete blood count, prothrombin time and activated partial thromboplastin time were also checked.
Mortality rate correlated strongly with initial severity of coagulopathy. Transfused pRBC volumes per hour were reduced significantly after rFVIIa (p=0.01), and coagulopathy was also significantly corrected. Thromboembolic events such as acute myocardial infarction and cerebrovascular attack, a fatal complication of rFVIIa, did not occur.
The administration of rFVIIa can correct hemorrhage associated coagulopathy and reduce pRBCs transfusion volume. A quick decision regarding the administration of rFVIIa is needed for a more favorable outcome in multiple-injury patients with hemorrhagic shock.
Key words: rFVIIa, Transfusion volume, Coagulopathy, Multiple trauma, Hemorrhagic shock
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