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J Korean Soc Emerg Med > Volume 22(2); 2011 > Article
Journal of The Korean Society of Emergency Medicine 2011;22(2): 151-155.
Emergency Department-Based Treatment of Acute Ureteral Colic with Hydromorphone and Pethidine: Prospective, Randomized Control Trial
Wook Jin Choi, Won Young Kim, Chang Hwan Sohn, Jeong Min Ryu, Dong Woo Seo, Jae Ho Lee, Youn Sun Lee, Bum Jin Oh, Won Kim, Kyoung Soo Lim
Department of Emergency Medicine, College of Medicine University of Ulsan, Asan Medical Center, Seoul, Korea. wonpia@yahoo.co.kr
ABSTRACT
PURPOSE:
To compare the efficacies and side effects of intravenous hydromorphone and pethidine in the emergency department (ED) treatment of ureteral colic.
METHODS:
A prospective, controlled, randomized clinical trial was conducted in a university-affiliated tertiary referral center. All adult patients who presented to the ED with severe ureteral colic were included. The patients received either 1 mg of hydromorphone (n=26) or 50 mg of pethidine (n=26) intravenously. Pain intensity was determined using a 10 cm visual analogue scale 0, 15, 30, and 120 minutes after injection.
RESULTS:
Dermographic characteristics and baseline pain scores of both groups were comparable (p>0.05). The pain intensity level for the hydromorphone group was lower than for the pethidine group at 15, 30, and 120 minutes. Pain relief was better with hydromorphone at 15 minutes (p<0.05). Side effects of the two groups were not statistically significant.
CONCLUSION:
The ureteral colic patients receiving hydromorphone achieved more pain relief. The side effects were similar for either treatment. Hydromorphone should be the preferred agent in suspected ureteral colic, when an opioid analgesic is to be used.
Key words: hydromorphone, pethidine, ureteral colic
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