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J Korean Soc Emerg Med > Volume 25(6); 2014 > Article
Journal of The Korean Society of Emergency Medicine 2014;25(6): 771-774.
The Experience and Management of Two Cases of Metformin-associated Lactic Acidosis
Hyeuk Soo Lee, Choong Sil Seong, Byung Sun Kim, Woong Ki Lee, Hye Mi Choi, Hyun Ju Yoon, Jeong Gwan Kim, In O Sun, Kwang Young Lee
Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea. kwangpmc@daum.net
Metformin, a dimethylbiguanide, is an oral antihyperglycemic drug used in treatment of type 2 diabetes mellitus. It has been reported that metformin may be associated with lactic acidosis in patients with clinical conditions such as renal failure and heart failure. Metformin-associated lactic acidosis (MALA) is a rare, but serious complication with a mortality rate of approximately 30~50%. Therefore, an aggressive treatment strategy including hemodialysis is recommended for these patients. Although continuous renal replacement therapy (CRRT) has been administered in hemodynamically unstable patients with MALA, there are few case reports describing the use of CRRT as a therapeutic modality in Korea. Here, we describe the case histories of two MALA patients who underwent treatment with CRRT.
Key words: Metformin, Acidosis, Lactic, Renal replacement therapy
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