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J Korean Soc Emerg Med > Volume 26(3); 2015 > Article
Journal of The Korean Society of Emergency Medicine 2015;26(3): 248-255.
The Factors Associated with the Hypotension Development in Acute Glyphosate-surfactant Herbicide Poisoning
Dong Kyu Kim, Yong Hwan Kim, Jun Ho Lee, Seong Yun Hwang, Kwang Won Cho, Mun Ju Kang, Dong Woo Lee, Young Hwan Lee, Kyoung Yul Lee, Na Kyung Lee
1Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. suka1212@naver.com
3Department of Emergency Medicine, Hallym University Sungsim Hospital, Hallym University College of Medicine, Anyang, Korea.
4Department of Physical Eduation, Kyungnam University, Changwon, Korea.
5Department of Nursing, Graduate School, Kyung Hee University, Seoul, Korea.
Recently, glyphosate-surfactant herbicide has been used increasingly because it is known for its low toxicity in mammals. However, some cases presented severe clinical complications including hypotension. Previous studies have shown that hypotension is a predictor of poor outcome and mortality. Therefore, we aimed to identify factors that may be related to hypotension in glyphosate intoxication.
This retrospective study targeted patients with glyphosate intoxication who were admitted to the emergency department of a single hospital from January 1st, 2004 to November 2014. The data were collected retrospectively from clinical records and laboratory files. Using multivariate logistic analysis, data were analyzed retrospectively for association with hypotension.
Of the 245 patients, 63 patients (25.7%) had hypotension. The results of this study showed statistically significant differences in old age, underlying disease, amount of ingestion, GCS (Glasgow coma scale), White blood cell, hemoglobin, total bilirubin, glucose level, pH, bicarbonate, base excess, lactate level, AST (aspartate aminotransferase), creatinine level, saturation, Chest X-ray abnormality, and prolonged QTc (corrected QT interval) between hypotension group and non-hypotension group. By multivariate logistic analysis, GCS, creatinine level, chest X-ray abnormality, and prolonged QTc interval were associated with the cases presenting with hypotension.
GCS, creatinine level, chest X-ray abnormality, and prolonged QTc interval were significant factors associated with hypotension in patients with glyphosate intoxication.
Key words: Glyphosate, Hypotension, Mortality
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