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J Korean Soc Emerg Med > Volume 23(1); 2012 > Article
Journal of The Korean Society of Emergency Medicine 2012;23(1): 149-153.
Clinical Experiences Treating Edifenphos and Iprobenfos Intoxication Patients
Sun pyo Kim, Kyung hoon Sun, Dae hyuk Choo, Soo hyung Cho
Department of Emergency Medicine, College of Medicine, Chosun University, Gwangju, Korea. chosooh@naver.com
ABSTRACT
Organophosphate fungicides include edifenphos, iprobenfos and tolclofos-methyl. Edifenphos inhibits cell wall synthesis by reduction in chitin synthase activity and inhibits the action of acetylcholinesterase. Thus, exposure to this chemical results in excessive salivation, lacrimation, urination, defecation, gastrointestinal motility and emesis symptoms, just like other organophosphate insecticides. Although edifenphos is an organophosphate fungicide, it is the only agricultural chemical which inhibits the action of pralidoxime and atropine, an activity which in turn, inhibits treatment. Thus, we have to treat these cases as soon as possible with atropine and pralidoxime, using the same approach as used for exposure to other organophosphate insecticides. In this report we evaluate the results of treatment of 4 patients who were intoxicated by fungicides (3 cases with edifenphos and 1 case with iprobenfos).
Key words: Fungicides, Edifenphos, Iprobenfos
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