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J Korean Soc Emerg Med > Volume 33(5); 2022 > Article
Journal of The Korean Society of Emergency Medicine 2022;33(5): 506-515.
Effect of post-treatment fluvastatin for hemorrhagic shock in rats
Oh Hyun Kim1 , Soo-Ki Kim2 , Soon-Hee Jung3 , Sung Oh Hwang1 , Hyun Kim1 , KyoungChul Cha1 , Yong Sung Cha1 , Gyo Jin An1 , Kang Hyun Lee1
1Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
2Department of Microbiology, Yonsei University Wonju College of Medicine, Wonju, Korea
3Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea
Correspondence  Kang Hyun Lee ,Tel: 033-741-1612, Fax: 033-742-3030, Email: ed119@yonsei.ac.kr,
Received: September 30, 2021; Revised: December 2, 2021   Accepted: February 8, 2022.  Published online: October 31, 2022.
This study aimed to investigate the biochemical, histologic, and immunologic effects of post-treatment administration of fluvastatin in a hemorrhagic shock (HS) rat model.
Experimental rats were randomly divided into four groups: control group: no drugs and did not undergo HS; control statin group: fluvastatin 1 mg/kg (no HS); HS group: normal saline after HS; HS+statin group: fluvastatin 1 mg/kg+normal saline after HS. Briefly, HS was induced by femoral arterial catheter blood extraction of 30% of the total blood volume. The mean arterial pressure and heart rate were monitored for 2 hours after starting blood withdrawal. Arterial blood gas, complete blood count, and serum cytokine levels were measured at baseline, 2 hours after HS, and 48 hours after resuscitation. The kidneys, lungs, and small intestines were removed for pathological examination 48 hours after HS.
At the end of the resuscitation period, the HS and HS+statin groups showed reduced bicarbonate, base excess, and platelet counts, all of which differed significantly from values in the control and control+statin groups. Compared to the control group, the HS+statin group exhibited significantly elevated serum interleukin-10 (IL-10) at 2 hours after resuscitation (P<0.05). Except for IL-10, the group-time interaction was not significant for other cytokine profiles.
This study demonstrates that post-treatment with fluvastatin after HS increases the production of the anti-inflammatory cytokine IL-10 and affects the cytokine profiles in rats.
Key words: Hemorrhagic shock; Traumatic shock; Cytokines; Hydroxymethylglutaryl-CoA reductase inhibitors
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