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Journal of The Korean Society of Emergency Medicine 1996;7(4): 530-539. |
| EFFECTS OF EARLY HEPARINIZATION IN ACUTE CEREBRAL INFARCTION |
| Gab Teug Kim1, Jong An Lee1, Hwa Sik Song1, Keun Ho Lee2 |
1Department of Emergency Medicine, College of Medicine, Dankuk University, Chunan, Korea
2Department of Neurology, College of Medicine, Dankuk University, Chunan, Korea |
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Published online: December 31, 1996. |
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| ABSTRACT |
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To evaluate efficacy and safety of early heparin anticoagulation in patients with acute cerebral infarction, 114 cases were treated (46 cases with heparin treatment and 68 cases non-heparin treatment). Heparin sodium was administered intravenously starting with a bolus of 5000 U, followed by continuous infusion over 4 days at a rate adjusted to maintain an activated partial thromboplastin time(aPPT) ratio between 2 and 2.5. The clinical variables which were examined were neurological deficits on admission, clinical severity of infarction on admission, location of infarcts,and infarct size. Short-term outcome and long-term outcome were improved with heparin treatment. With heparinization the conditions of 22 patients(47.8%) improved by day 7, while 17(25.0%) patients improved in no heparinization. Thirty-seven patients(80.4%) with heparinization had good outcome in 3 month after onset, but thirty-nine patients(57.4%) without heparinization had good outcome. The hemorrhagic complication did not correlate with heparinization. Four patients(8.7%) with heparinization and five patients(7.4%) without heparinization were suffered cerebral hemorrhage. |
| Key words:
Cerebral infarction, Heparinization, Efficacy, Safety, Cerebral hemorrhage |
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