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J Korean Soc Emerg Med > Volume 7(4); 1996 > Article
Journal of The Korean Society of Emergency Medicine 1996;7(4): 511-520.
EMERGENCY PULMONARY FUNCTION TEST FOR ASTHMATIC PATIENTS TREATED WITH SALBUTAMOL THERAPY
Sung Tae Ahn, Yong Joo Lee, Jun Hee Lee, Seung Tae Han, Kwang Je Baek
Department of Emergency Medicine, College of Medicine, Inha University, Korea
  Published online: December 31, 1996.
ABSTRACT
The study was designed prospectively to evaluate the time related response to repeated salbutamol inhalation therapy. Clinical improvement in asthmatic patients treated with bronchodilators has been observed, however, objective data is lacking. The adequacy of therapy was assessed by analyzing pulmonary function test (PFT) in 32 patients with acute asthma presented at our emergency department from August 1, 1994 to March 31, 1996. Each patient inhalated salbutamol solution (5 mg diluted in 2 ml saline) for 5 minutes initially, and second dose was applied 30 minutes thereafter. We measured pretreatment and posttreatment PFTs including forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEER), 30 minutes after each salbutamol inhalation by using the Micro Spirometer and Mini-Wright peak flow meter (Micro Medical Ltd,England). Changes of PFT values were analysed statistically in all instances by means of paired t-test, and p-value of less than 0.05 was designated significant. The following results were obtained; 1. Pretreatment PFT showed FEV1 1.07土0.61 liter, FVC 1.29 土0.72 liter, and PEFR 174.69士99.58 liter/min. 2. Posttreatment PFT, 30 minutes after initial salbutamol inhalation, showed FEVl 1.60士0.48 liter, FVC 1.85 土0.51 liter, PEFR 232.88 土91.28 liter/min. 3. Posttreatment PIT, 30 minutes after second dose of salbutamol inhalation, showed FEV1 2.00士0.48 liter, FVC 2.14土0.63 liter, PEFR 282.34土97.79 liter/min. From the above data, we conclude that FEV1, FVC, and PEFR in asthmatic patients have been improved consistently after salbutamol inhalation therapy (p<0.001), and an additional salbutamol therapy improves FEV1 significantly (p<0.005), but FVC and PEFR substantially.
Key words: Emergency pulmonruy function test, Asthma
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