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J Korean Soc Emerg Med > Volume 7(2); 1996 > Article
Journal of The Korean Society of Emergency Medicine 1996;7(2): 288-293.
A COMPARISON OF INTRAMUSCULAR PETHDINE, NALBUPHINE AND KETOROLAC IN THE ALLEVIATION OF RENAL COLIC
Sung Pil Chung, Sung Wook Choi, In Cheol Park, Seok Joon Jang, Hahn Shick Lee
Department of Emergency Medicine, Yonsei University College of Medicine
  Published online: June 30, 1996.
ABSTRACT
Ureter stone cause severe flank and abdominal pain. In emergency room, these patients require rapid pain relief and diagnosis. Therefore, authors have conducted a study on the efficacy of three types of commonly used analgesics including non opioid analgesics; intramuscular ketorolac 30mg and nalbuphine 10mg was compared with pethidine 50mg in 74 patients who visited SEVERANCE hospital emergency care center with complaint of flank colicky pain from Jan 1. 1996 to Mar 31. 1996. Pain was assessed before the drug administration, and then at 10min, 20min, 30min time interval after the first dose. Visual analogue scale was used to assess the pain intensity and scale was self drawn by each patient during the time of pain assessment. Additional need of rescue analgesia and adverse effecfs of first-line analgesia was also recorded. Statistical significant was confirmed using ANOVA and Chi square test. The difference in the decrease of pain intensity was not significant among the three analgesics(P =0.65). Rescue anagesia was required in 37.1% of pethidine, 42.8% of nalbuphine, 16.6% of ketorolac and totally 33.8%. The incidence of all types of adverse event of pethidine, nalbuphine and ketorolac were 14.2%, 14.2% and 5.5% in respectively. The results of this study have shown that non opioid analgesics are as effective as opioid analgesia Therefore, non opioid analgesics can be tried first line of pain relief drug of renal coliky pain with minimal adverse effects.
Key words: Renal colic, Pethidine, Nalbuphine, Ketorolac
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