| THE EFFECT OF HIGH DOSE EPINEPHRINE DURING CPR OF CARDIAC ARREST |
| Yoo In Sool, Park Jae Hwang |
| Wonkwang University Hospital Department of Emergency Medicine |
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Published online: July 31, 1994. |
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| ABSTRACT |
Study objectives ; To compare the return of spontaneous circulation(RSC) rates in cardiac arrest treated with standard doses of epinephrine (SDE) or high dose epinephrine (HDE).
Design ; prospective.
Setting ; The WonKwang university hospital emergency department during July, 1991 through December, 1993.
Participants ; 56 adult victims of nontraumatic cardiac arrest.
Interventions ; At the discretion of the treating physician, patients received epinephrine
in bolus doses ranging from 1 to 15mg. HDE was defined as a dose of at least 0.15mg/ kg ; smaller doses were defined as SDE. Patient was grouped as +RSC if they developed
a sustained spontaneous palpable pulse or blood pressure and as -RSC if they did not
develop a pulse or blood pressure.
Measurements ; Patients were grouped as +RSC and -RSC. Patients were also grouped by their presenting rhythm. Potentially perfusing rhythm was electromechanical dissociation or ventricular tachycardia. Nonperfusing rhythm was asystole or ventricular fibrillation. Rate were analyzed using the Chi 一square test and the two tailed unpaired tㅡ
test (p=0.185). The effects were greatest in patients with nonperfusing rhythms(p=0.
119). One patient survived to hospital discharge.
Conclusion
; High dose epinephrine improves initial resuscitation rates in cardiac arrest. Its greatest effect is in patients with a nonperfusing rhythm.
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