Correlation between hs-CRP and CRP velocity and in-hospital short term prognosis in acute myocardial infarction, which arrived in the ER within 6 hours after symptoms are expressed

Park, Jin Won; Cho, Tae Jin; Kwak, Sae Jeung; Yun, Sung Hyun

J Korean Soc Emerg Med > Volume 32(1); 2021 > Article

Original Article

Journal of The Korean Society of Emergency Medicine 2021;32(1): 19-26.

증상 발현 후 6시간 이내 응급실 도착한 급성심근경색증에서 hs-CRP 및 CRP velocity와 재원 기간 내 단기 예후와의 상관 관계

박진원

, 조태진

, 곽세정

, 윤성현

가톨릭관동대학교 국제성모병원 응급의학과

Correlation between hs-CRP and CRP velocity and in-hospital short term prognosis in acute myocardial infarction, which arrived in the ER within 6 hours after symptoms are expressed

Department of Emergency Medicine, Catholic Kwandong University International St. Mary’s Hospital, Incheon, Korea

Correspondence

Sung Hyun Yun ,Tel: 032-290-3030, Fax: 032-290-2886, Email: jimin0415@ish.ac.kr,

Received: February 17, 2020; Revised: May 13, 2020 Accepted: July 17, 2020. Published online: February 26, 2021.

ABSTRACT

Objective:
This study is to measure the high sensitivity C-reactive protein (hs-CRP) value in acute myocardial infarction (AMI) patients who arrive within 6 hours of the symptom manifestation and see how the resulting value affects the short term prognosis in AMI patients.
Method:
This study was conducted on 118 patients who had less than 6 hours of onset-to-door time among 149 patients who were diagnosed with myocardial infarction in emergency room and undergo percutaneous coronary intervention (PCI) for 2 years from September 2017. The group including main adverse cardiovascular outcomes were compared in the patients according to the blood test figures (hs-CRP on admission [CRP1], CRP velocity [CRPv], post-PCI hs-CRP [CRP2], and CRP difference values [CRP2-1]).
Results:
In this study, the average of the hs-CRP values of AMI patients arriving within 6 hours of the symptom manifestation was 2.2±2.3 mg/L. CRP velocity that corrected the CRP value to the elapsed time after the onset of symptoms and N-terminal probrain natriuretic peptide (NT-proBNP) appeared to be significantly correlated with the occurrence of main adverse cardiovascular outcomes (P=0.03).
Conclusion:
The hs-CRP values of AMI patients arrived within 6 hours of the symptom manifestation showed the mean risk group. CRPv and NT-proBNP showed a significant casual relationship with main adverse cardiovascular outcomes.

Key words: hs-CRP; Velocity; Acute myocardial infarction