| Home | E-Submission | Sitemap | Contact Us |  
J Korean Soc Emerg Med > Volume 30(3); 2019 > Article
Journal of The Korean Society of Emergency Medicine 2019;30(3): 208-216.
Targeted temperature management is related to improved clinical outcome of out-of-hospital cardiac arrest with non-shockable initial rhythm
Seok Goo Kim , Won Chul Cha , Min Seob Sim, Sung Yeon Hwang , Tae Gun Shin , Joo Hyun Park, Hee Yoon , Ik Joon Jo, Jin-Ho Choi
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence  Jin-Ho Choi ,Tel: 02-3410-2053, Fax: 02-3410-3849, Email: jhchoimd@gmail.com,
Received: August 24, 2018; Revised: October 1, 2018   Accepted: October 3, 2018.  Published online: June 30, 2019.
The benefits of targeted temperature management (TTM) for resuscitated out of hospital cardiac arrest (OHCA) with an initial non-shockable rhythm are still unclear. This study examined whether TTM reduces the mortality and improves the neurological outcomes of OHCA with a non-shockable initial rhythm.
This study analyzed the clinical outcome of 401 resuscitated patients with an initial non-shockable rhythm among a total of 1,616 OHCA patients who were registered in Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance. The impact of TTM was investigated after accounting for the patients’ propensity for TTM. The primary outcome was a 30-day in-hospital course with a neurologically favorable outcome defined by a cerebral performance categories scale ≤2.
TTM was performed in 89 patients (22%) with an initial non-shockable rhythm. Patients who has received TTM had a tendency to be younger, more likely to be female, and more likely to undergo percutaneous coronary intervention. The clinical outcome of the patients in the initial non-shockable rhythm treated by TTM was superior to those without TTM (hazard ratio [HR], 0.36; 95% confidence interval [CI], 0.27-0.46). Further analysis after propensity score matching or inverse probability of treatment weighting (IPTW) showed consistent findings (propensity score matching: HR, 0.32; 95% CI, 0.22-0.45; IPTW: HR, 0.40; 95% CI, 0.31-0.52; P<0.001, all).
In this nationwide OHCA registry, TTM was related to an approximately three-fold better 30-day neurologically favorable survival of resuscitated patients with TTM treatment than patients without TTM in the initial non-shockable rhythm.
Key words: Out-of-hospital cardiac arrest; Induced hypothermia; Cardiopulmonary resuscitation; Prognosis
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
Related article
The Factors Influencing Neurological Outcome of Out-of-hospital Cardiac Arrest with Cardiac Etiology  2016 April;27(2)
Editorial Office
The Korean Society of Emergency Medicine
TEL: +82-62-226-1780   FAX: +82-62-224-3501   E-mail: 0012194@csuh.co.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Emergency Medicine.                 Developed in M2PI