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J Korean Soc Emerg Med > Volume 27(5); 2016 > Article
Journal of The Korean Society of Emergency Medicine 2016;27(5): 488-491.
A Case of Methanol Poisoning Treated with Continuous Renal Replacement Therapy - The Serial Measurements of Serum Methanol Concentrations in Methanol Poisoning -
Hyun Ju Yang1, Soo-Wan Chae2, Soon-Ok Noh3, Yun Jo Chung4, Sung Sik Oh1, Mi Rim Choi1, Jong Wha Lee1, Myung Woo Choi1, Hyun Ju Yoon1, In O Sun1, Kwang Young Lee1
1Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea
2Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Korea
3Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea
4Center for University-wide Research Facilities, Chonbuk National University, Jeonju, Korea
Correspondence  Kwang Young Lee ,Tel: 063-230-1331, Fax: 063-230-1309, Email: kwangpmc@hanmail.net,
Received: May 9, 2016; Revised: May 10, 2016   Accepted: July 12, 2016.  Published online: October 30, 2016.
ABSTRACT
Methanol poisoning is a medical emergency that requires rapid elimination of the toxin and its metabolites for recovery. The danger of methanol results from the accumulation of its toxic metabolite formic acid. This accumulation may result in the development of metabolic acidosis, visual impairment, and damage to the basal ganglia. Extracorporeal treatment is recommended in severe cases of methanol poisoning with coma, seizure, new vision deficits, metabolic acidosis, high serum anion gap, elevated methanol concentrations or impaired kidney function. Although the serum methanol concentration is helpful in determining the use of extracorporeal treatment, methanol assays are not standard laboratory tests in Korea. Herein, we report a case of methanol poisoning in which the patient’s clinical improvement was confirmed using serum and urine methanol levels.
Key words: Extracorporeal circulation, Methanol, Osmolar concentration, Poisoning
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