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Journal of The Korean Society of Emergency Medicine 1998;9(4): 571-577. |
| Patterns of Serum Interleukin-6 Concentration after Initial Successful Cardiopulmonary Resuscitation |
| Kyu Nam Park, Seung Hyun Park, Du Young Hwang, Hyung Guk Kim, Hwan Lee, Kyung Ho Choi, Won Jae Lee, Uk Sung Jung, Hak Ju Kim, Se Kyung Kim |
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| ABSTRACT |
OBJECTIVE: To investigate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL16 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR).
METHODS:
We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation.
Venous blood samples were taken 2,4,12,24,48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay.
RESULTS:
Serum IL-6 concentrations in the severe neurologically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurologic disabled group showed dual peak at 4 and 24 hours.
CONCLUSION:
Our study demonstrates significant incense of seam IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation. |
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