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J Korean Soc Emerg Med > Volume 11(4); 2000 > Article
Journal of The Korean Society of Emergency Medicine 2000;11(4): 506-515.
Clinical Significance of Myocardial Injuries in Patients with Nontraumatic Intracraninal Hemorrhage
Gu Hyun Kang, Sung Oh Hwang, Kang Hyun Lee, Jun Hwi Cho, Seong Whan Kim, Joong Bum Moon, Hae Sang Park, Seo Young Lee, Sung Soo Lee, Hun Joo Kim
OBJECTIVE: The aim of this study was to investigate the clinical significance of myocardial injuries in patients with nontraumatic intracranial hemorrhage by identifying the occurrence of myocardial injury and defining its correlation with subsequent cardiovascular events. SUBJECTS AND
One hundred twenty-four patients with nontraumatic intracraninal hemorrhage presented to the emergency department within six hours from onset of symptoms were enrolled. Brain CT, serial electrocardiography, and echocardiography were done at the emergency center. Blood samples for troponin I and creatine kinase(CK)-MB were drawn immediately and eight hours after admission. Troponin I and CK-MB were measured using a chemiluminescent immunoassay, respectively.
Electrocardiographic and echocardiography abnormalities were found in 65 cases(52.4%) and 21 cases(17%), respectively. Serum troponin I and creatine kinase-MB were increased in 35 cases (28.2%) and in 58 cases(46.8%), respectively. Abnormal findings of echocardiography and ECG, as well as elevated levels of serum troponin I and creatine kinase-MB, were associated with an increased risk of cardiovascular event and survival. Logistic regression analysis revealed that an abnormal echcocardiographic finding and elevation of serum troponin I were factors associated with the occurrence an adverse cardiovascular event and that electrocardiographic abnormalities and initial mental status were factors associated with poor prognosis.
This study reveals that actual myocardial injury develops in a significant proportion of patients with nontraumatic intracranial hemorrhage and that the development of the myocardial injury is associated with an adverse cardiovascular event that occurs during admission.
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