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J Korean Soc Emerg Med > Volume 12(4); 2001 > Article
Journal of The Korean Society of Emergency Medicine 2001;12(4): 536-540.
A Case of Primary Central Nervous System Lymphoma with Panhypopituitarism
Won Young Kim, Won Kim, Gyu Chong Cho, Jung Suck Hong, Mi Woo Lee, Sung Eun Jang, Se Hyun Oh, Kyoung Soo Lim
1Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Korea. wonpia@yahoo.co.kr
2Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Korea.
3Department of Emergency Medicine, Kangnung Hospital, Korea.
A primary central nervous system lymphoma(PCNSL) is defined as a lymphoma limited to the cranialspinal axis without systemic involvement. PCNSLs were formerly very rare, only 0.5~1.2% of all intracranial neoplasms, and were usually associated with acquired immuno-deficiency syndrome(AIDS) and other immuno-compromised states. Recently, there has been a clear rise in the incidence of this disease among normal individuals. We describe a 77-year-old female with hyponatremia who presented with a confused mental state. Computed tomography(CT) of the brain demonstrated a suprasellar mass with enhancement. We evaluated the basic hormonal studies and the magnetic resonance imaging(MRI). A ventricular biopsy was done, and the result was a diffuse, large, B-cell-type malignant lymphoma. She presented panhypopituitarism and partial central diabetes insipidus. She received chemotheraphy and was discharged in an improved condition. We report a case of panhypopituitarism due to PCNSL and give a review of the literature.
Key words: Primary central nervous system lymphoma, Panhypopituitarism
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