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J Korean Soc Emerg Med > Volume 16(6); 2005 > Article
Journal of The Korean Society of Emergency Medicine 2005;16(6): 667-676.
Korean Multicenter Study of Te tanus Antibody Titer (KoMUST)
Ho Jung Kim, Gu Hyun Kang, Gi Woon Kim, Sang Chul Kim, Young Sik Kim, Chun Ho Kim, Hee Cheol Ahn, Se Hyun Oh, Yoo Sang Yoon, Kang Hyun Lee, Sam Woo Lee, Jae Bae Lee, Jin Woong Lee, Tai Ho Im, Jae Bong Chung, Soo Hyeong Cho, Kwang Won Cho, Jun Hwi Cho, Jin Kyung Cho, Michael SungPil Choi, En Seok Hong, Yong Hwa Lee
1Department of Emergency Medicine, Soonchunhyang University (Bucheon). lovelydr@schbc.ac.kr
2Department of Emergency Medicine, Hallym University (Kangnam).
3Department of Emergency Medicine, Ajou University.
4Department of Emergency Medicine, Pocheon Medical Center.
5Department of Emergency Medicine, Dae Jin Medical Center.
6Department of Emergency Medicine, Suncheon Jungang Hospital.
7Department of Emergency Medicine, Hallym University (Chuncheon).
8Department of Emergency Medicine, Ulsan University (Gangneung).
9Department of Emergency Medicine, Yonsei University (Seoul).
10Department of Emergency Medicine, Yonsei University (Wonju).
11Department of Emergency Medicine, Pohang St. Mary's Hospital.
12Department of Emergency Medicine, Chonbuk University.
13Department of Emergency Medicine, Kunkuk University (Chungju).
14Department of Emergency Medicine, Hanyang University.
15Department of Emergency Medicine, Jeju Halla Hospital.
16Department of Emergency Medicine, Chosun University.
17Department of Emergency Medicine, Sungkyunkwan University (Masan).
18Department of Emergency Medicine, Kangwon University (Chuncheon).
19Department of Emergency Medicine, NHIC Ilsan Hospital.
20Department of Emergency Medicine, Pocheon CHA University (Kumi).
21Department of Emergency Medicine, Ulsan University.
22Department of Laboratory Medicine, Soonchunhyang University (Bucheon), South Korea.
ABSTRACT
PURPOSE:
We determine the Korean antibody titer and positive rate of tetanus by using a with qualitative test (ELISA) and a quantitative test (TQS(R)).
METHODS:
This study was prospective collecting study with uncontolled patients who were admitted in 21 Emergency Departments during 3 months in South Korea. We measured TQS(R) and collected the serum with a centrifuge for 5 groups, which was classified with age: 2~10 years (I), 11~20 years (II), 21~30 years (III), 31~40 years (IV), 41~60 years (V), in each hospital. The freezed serum and the protocol with TQS(R) results were taken at the Soonchunhyang University Bucheon hospital to be analyzed.
RESULTS:
The number of enrolled patients was 1816 (male 58%). The positive rate of TQS(R) was 835 patients (46%), and there was no relation with region or sex. In sex and age, there was a definitive decline in the group III fort males and females. The results of ELISA was showed that 62.8% (> 0.15 IU/ml) and 52.2% (> 0.2 IU/ml) had protective levels of tetanus antibody. The proportion decreased to approximately 43% and 18% among persons 40~60 years of age at each level of antibody titers. By region and population, there was no statistical relationship with TQS(R) and ELISA, but previous military service was associated with a higher prevalence of protective antibodies to tetanus (p<0.001).
CONCLUSIONS:
A substantial portion of adults in South Korea do not have antibody levels that are protective against tetanus. Also, the mean level of tetanus antibody titers was definitively lower than those of other developed conturies and consistently decreased with aging. Therefore, an adult formulation diphteria and tetanus toxoid every 5 or 10 years is recommended for all adults between 20 and 60 years of age after being tested with TQS(R) in South Korea.
Key words: Tetanus antibody, Epidemiology, Korean
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