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J Korean Soc Emerg Med > Volume 26(3); 2015 > Article
Journal of The Korean Society of Emergency Medicine 2015;26(3): 263-268.
A Case of Acute Kidney Injury in A 62 Year Old Man Who Took Atractylodes Macrocephala Koidzumi
So Hee Chung, Ki Tae Bang, Kyoung Min Moon, Young Min Rah, Hyeon Jeong Yun, Min Kyu Kang, Jin Young Kim, Ju Ri Kim, Dong Kyu Lee, Jun Hyung Park, Young Hun Kim
Department of Internal Medicine, Eulji University Hospital Eulji University Medical School, Daejeon, Korea. starryroom@eulji.ac.kr
ABSTRACT
The drug inducing tubulointerstitial nephritis is a crucial cause of acute kidney injury. Use of herbal plants in disease treatment is generally practiced in Korea. Although there are a small number of case reports, tubulointerstitial nephritis caused by taking Atractylodes macrocephala Koidzumi in human has never been reported. A 62-year-old man visited our hospital with symptoms of systemic edema accompanied by reduced urine volume and dyspnea after taking herbal plant 1 week ago. Chest radiographs showed both sided pleural effusion. Blood test results showed elevation of serum blood urea nitrogen and creatinine level and urine test results showed hematuria and proteinuria. Renal biopsy result showed evidence of tubulointerstitial nephritis by tubulitis and inflammatory cell expansion in the interstitium was observed. The patient's renal function recovered after administration of active renal replacement treatment and conservative therapy such as supplementation of fluid and electrolytes, and there was no disease recurrence for 1 year. Therefore, this case proved that Atractylodes macrocephala Koidzumi could cause acute kidney injury by the drug induced tubulointerstitial nephritis in human.
Key words: Herbal medicine, Nephritis, Acute kidney Injury, Renal dialysis
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