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J Korean Soc Emerg Med > Volume 28(5); 2017 > Article
Journal of The Korean Society of Emergency Medicine 2017;28(5): 449-456.
Changes in Histopathology and Tumor Necrosis Factor-α Levels in the Hearts of Rats Following Asphyxial Cardiac Arrest
Jung Hoon Lee1, Tae-Kyeong Lee2, In Hye Kim2, Jae Chul Lee2, Moo-Ho Won2, Joon Ha Park3, Ji Hyeon Ahn3, Myoung Chul Shin1, Taek Geun Ohk1, Joong Bum Moon1, Jun Hwi Cho1, Chan Woo Park1*, Hyun-Jin Tae4*
1Department of Emergency Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea
2Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea
3Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon, Korea
4Bio Safety Research Institute, Chonbuk National University College of Veterinary Medicine, Iksan, Korea
Correspondence  Chan Woo Park ,Tel: 033-258-2292, Fax: 033-258-2451, Email: bonaeboa@naver.com,
Hyun-Jin Tae ,Tel: 063-850-0957, Fax: 063-850-0910, Email: hjtae@jbnu.ac.kr,
Received: May 8, 2017; Revised: May 16, 2017   Accepted: June 14, 2017.  Published online: October 31, 2017.
ABSTRACT
Purpose:
Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have a return of spontaneous circulation (ROSC) after the CA. The aim of this study was to examine the histopathology and inflammatory response in the heart during post CA syndrome.
Method:
Asphyxial CA was induced in male Sprague-Dawley rats and the survival rate of the rats was determined during the post resuscitation phase.
Results:
Survival of the rats decreased after CA: 66.7% at 6 hours, 36.7% at 1 day, and 6.7% at 2 days after the ROSC following CA. The rats were sacrificed at 6 hours, 12 hours, 1 day, and 2 days after the ROSC, and their heart tissues were examined. Histopathological scores increased at 12 hours post CA. Afterwards, the histopathological changes were not significant. In addition, the levels of tumor necrosis factor-α immunoreactivity increased gradually after CA.
Conclusion:
The survival rate of the rats 2 days post CA was very low, even though the histopathological and inflammatory changes in the heart were not pronounced in the early stages following the CA.
Key words: Cardiac arrest, Heart, TNF-alpha
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