|
|
Journal of The Korean Society of Emergency Medicine 2003;14(5): 624-629. |
| B-Natriuretic Peptide (BNP) Assay for Diagnosis of Congestive Heart Failure |
| Won Kim, Won Young Kim, Yong Taeg Jung, Kyoung Soo Lim, Yun Kyung Park |
1Department of Emergency Medicine, Gang Nung Asan Hospital, University of Ulsan College of Medicine, Korea.
2Department of Emergency Medicine, Asan Medical Center, Seoul, Korea.
3Hanil Clinic, Seoul, Korea. |
|
|
|
|
|
| ABSTRACT |
PURPOSE:
Rapid diagnosis of congestive heart failure (CHF) is important for prompt and appropriate treatment, but is often difficult. The B-type natriuretic peptide (BNP) has been described as a powerful diagnostic test for heart failure. The goal of this study was to determine the diagnostic cutoff values of BNP, to evaluate useful factors for the diagnosis of CHF, and to develope a diagnostic algorithm for CHF with acute dyspnea patients.
METHODS:
BNP levels were obtained in 721 patients presenting to the emergency medical center with acute dyspnea from January 2001 to December 2002. With the use of inclusion criteria, 305 patients were excluded. Blood samples were collected by venipuncture and were analyzed by using Triage BNP assay. Included patients underwent echocardiography to evaluate the left ventricular (LV) dysfunction.
RESULTS:
The mean BNP concentration was higher in patients with CHF (n=214) than in those with other diagnose (517.31+/-37.70 pg/mL vs 75.53+/-11.25 pg/mL, p<0.001). At a blood concentration of 100 pg/mL, BNP showed a sensitivity of 79 %, a specificity of 83 %, a positive predictive value of 83%, and a negative predictive value of 79%.
CONCLUSION:
The BNP measurement is a useful tool in the diagnosis of CHF in patients presenting with dyspnea. We propose a diagnostic algorithm for CHF based on the BNP assay. |
| Key words:
Coagestive heart failure, Natriuretic peptide, Brain (BNP) |
|
|
|
PDF Links
Full text via DOI 
Download Citation 
